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Ms. Santhinissi Addala

M.Sc. (Biochemistry)

Juniorette Assistant Professor,

Head of the Branch (HoB),

Stem Cell Biology Branch, 

Department of Intramural Research Core (IRC)

The Center for Advanced-Applied Biological Sciences & Entrepreneurship (TCABS-E), Visakhapatnam (A.P.) India.

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Telephone: +91 8660301662; Email: tcabse.india(at)gmail(dot)com.

NIH Biosketch coming soon...

Research Interests: Stem Cell Biology Applications

Stem cells are critical in a lot of medical applications these days because of their high proliferative capacity and self-renewal characteristics. There are many sources for adult stem cells such as the embryo and bone marrow. However the stem cell acquisition from bone marrow is not only invasive but also painful while embryonic stem cell acquisition has ethical issues. In order to circumvent such hurdles the endometrium-derived menstrual stem cells (MnSc) were chosen as a potential source of adult stem cells for organoid development. MnScs can be obtained from volunteers in a non-invasive method and have been previously shown to have differentiation capabilities although not as efficiently as the embryonic stem cells. In this study, the MnScs will be used to develop organoids that have a plethora of medical applications.

Publications (Listed Chronologically)

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  1. Addala, S., Yedidi, R.S. (2020) Impact of COVID-19 on culture and society TCABSE-J, Spl. issue 1:17-21. Epub: Oct25 th , 2020. (View publication)​

  2. Vissapragada, M., Addala, S., Sodasani, M., Yedidi, R.S. (2021) Major structural deviations in the receptor binding domain of SARS-CoV-2 spike protein may pose threat to the existing vaccines. TCABSE-J, Vol. 1, Issue 1:12-14. Epub: Apr 13th, 2021. (View publication)

  3. Addala, S., Yedidi, R.S. (2021) Potential role of vaginal microbiome on the viability of endometrium-derived stem cells for organoid development. TCABSE-J, Vol. 1, Issue 2:31-32. Epub: Oct15 th , 2021. (View publication)

  4. ​Vissapragada, M., Addala, S., Grandhi, A.V.K.S., Gampa, S., Yedidi, R.S. (2021) Analysis of the wild type SARS-CoV-2 spike protein-mRNA secondary structure stability to predict viral fitness. TCABSE-J, Vol. 1, Issue 2:38-40. Epub: Oct15th , 2021. (View publication)

  5. Gampa, S., Aggunna, M., Grandhi, A.V.K.S., Adduri, V., Ayithamsetti, P., Korabu, M., Addala, S., Vissapragada, M., Palakurty, M., Yedidi, R.S.  (2022) Increase in the predicted mRNA stability of certain SARS CoV-2 mutant spike proteins compared to wild type may pose potential risk to vaccines. TCABSE-J, Vol. 1, Issue 3:4-9. Epub: Apr 2nd, 2022. (View publication)

  6. Addala, S., Vissapragada, M., Aggunna, M., Mukala, N., Lanka, M., Gampa, S., Sodasani, M., Chintalapati, J., Kamidi, A., Veeranna, R.P., Yedidi, R.S. (2022) Success of Current COVID-19 Vaccine Strategies vs. the Epitope Topology of SARS-CoV-2 Spike Protein-Receptor Binding Domain (RBD): A Computational Study of RBD Topology to Guide Future Vaccine Design. Vaccines. 2022; 10(6):841. https://doi.org/10.3390/vaccines10060841

  7. Vissapragada, M., Addala, S., Aggunna, M., Mukala, N., Chintalapati, J., Kamidi, A., Korabu, M. S., Lanka, M., Palla, H., Sodasani, M., Grandhi, A. V. K. S., Unnisa, A., Adhikari, A., Kumpatla, A. D., Yerabolu, B., Paidi, C., Pemmadi, G., Penta, H., Mallavalli, H., Gadigoyala, K., Voleti, M., Ravilisetty, M., Akula, N., Gundubogula, P., Puripanda, P., Lankapalli, P., Sandipamu, P., Nagraj, R., Tamarala, R., Geddam, R., Kolluru, R., Oggu, R., Garbhapu, R., Meka, S., Geddam, S., Viyyapu, S., Sammangi, S., Javvaji, S., Chattopadhyay, S., Inemella, S., Grandhi, V., Chigilipalli, Y., Puppala, Y. C., Sharma, M. H., Gubbala, S., Thakur, K., Aanaparthi, S., Pothula, B. and Yedidi, R.S. (2022). In silico analysis of molnupiravir usage vs. efficacy of COVID-19 vaccines. TCABSE-J, Vol. 1, Issue 5:1-14. Mar 22nd, 2023. Epub: Oct 20th, 2022. (View publication)

  8. Addala, S., Gadigoyala, K., Sandipamu, P., Giduthuri, L.E., Samminga, L. and Yedidi, R.S. (2023). Comparative identification of the Lactobacillus spp. from yogurt/buttermilk samples and human vaginal swabs. TCABSE-J, Vol. 1, Issue 5:26-32. Mar 22nd, 2023. Epub: Mar 12th, 2023. (View publication)

  9. Karri, L., Sodasani, M., Addala, S., Grandhi, A.V.K.S., Chintalapati, J. and Yedidi, R.S. (2023). Proton-NMR-based comparative analysis of aqueous vs. organic extractions from Ficus religiosa with potential applications in the treatment of polycystic ovarian syndrome. TCABSE-J, Vol. 1, Issue 6:4-8. Epub: Aug 15 th , 2023. (View publication)

  10. Vissapragada, M., Gollu, S., Addala, S., Sodasani, M., Aggunna, M., Mukala, N., Pola, S., Panchagnula, B. and Yedidi, R.S. (2023). PCR amplification of wild type receptor binding domain coding gene of SARS CoV-2 spike protein for cloning into a bacterial expression vector. TCABSE-J, Vol. 1, Issue 6:18-23. Epub: Aug 20 th , 2023. (View publication)

  11. Simhadri, P.V., Addala, S., Sodasani, M. and Yedidi, R.S. (2024). Biodegradable organic perfumes are eco-friendly and healthy compared to the synthetic perfumes. TCABSE-J, Vol. 1, Issue 7:32-34. Epub: Jul 18 th , 2024. (View publication)

  12. Bellana, P., Eddumala, N., Pinipe, J., Marada, K., Mahapatro, R., Addala, S., Sodasani, M. and Yedidi, R.S. (2024). In vitro horizontal transfer of ampicillin-resistance gene between bacterial species with implications in antibiotic-resistance problem in human microbiome. TCABSE-J, Vol. 1, Issue 8:1-5. Epub: Jul 20 th , 2024. (View publication)

  13. Vissapragada, M., Addala, S., Aggunna, M., Sodasani, M., Grandhi, A.V.K.S. and Yedidi, R.S. (2024). Leveraging the potential of bacterial lateral gene transfer in boosting the efficacy of an edible probiotic prototype yogurt vaccine for COVID-19. Biochemical and Biophysical Research Communications, Vol. 734,150622. (View publication)

  14. Vissapragada, M., Aggunna, M., Tallapalli, M., Mandugula, H., Devandla, A., Yekula, A., Malapati, A., Bonala, S., Addala, S., Gudapati, S. and Yedidi, R.S. (2024) In silico prediction of COVID-19 vaccine efficacy based on the strain-specific structural deviations in the SARS CoV-2 spike protein receptor binding domain. Medical Research Archives, Vol. 12, No. 9. (View publication)

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